Page 35 - IJSA, Vol. 4, No 2, 2021

International Journal of Science Annals, Vol. 5, No. 1-2, 2022
рrint ISSN: 2617-2682; online ISSN: 2707-3637; DOI:10.26697/ijsa

Results Table 1
The flowcytometry findings of total of 43 cases of CML- Epidemiological Profile of Study Population
BP were retrieved from records. The patient’s mean age Patients
included in the study was 39.62±14.86 years. There Parameters Age range number percentage
were 24 males and 19 females (M:F=1.2:1) showing
male predominance. 27 patients were diagnosed with (n) (%)
myeloid blast crisis followed by 14 patients with B- Age 1-10 years 2 4.65
lymphoid blast crisis and 2 patients with mixed (n=43) 11-20 years 3 6.98
phenotypic acute leukemia (MPAL). Table 1 presents an 21-30 years 6 13.95
epidemiological profile of study population.
The mean age of patients in myeloid blast crisis, 31-40 years 14 32.56
lymphoid blast crisis, and mixed phenotypic acute 41-50 years 8 18.60
leukemia subgroups was 41.88±14.76, 34.79±15.30, and 51-60 years 7 16.28
44.00±8.49 respectively. There was no statically
significant correlation noted for age (p=0.331) and >60 years 3 6.98
gender (p=0.194) distribution in different subgroups of Total 43 100.00
blast crisis (Table 2). Gender
The results of present study showed that B-lymphoid (n=43) Male 24 55.81
blast crisis had aberrant co-expression of CD13 and Female 19 44.19
CD33 in four cases (28.57%) along with three case Total 43 100.00
(12.50%) of myeloid blast crisis having aberrant
expression of CD7 (Table 3).

Table 2
Age and Gender Distribution in Different Subgroups of Myeloid, Lymphoid and Mixed Phenotypic Acute Leukemia –
Blast Crisis
Myeloid blast crisis Lymphoid blast crisis Mixed phenotypic blasts
(n=27) (n=14) (n=2)
Parameters p-value
Mean Standard Mean Standard Mean Standard
deviation deviation deviation
Age (years) 41.88 14.76 34.79 15.30 44.00 8.49 0.331
Gender:
Male 17 62.96 7 50.00 0 0.00 0.194
Female 10 37.04 7 50.00 2 100.00

Table 3
Immunophenotypic Profiles in Cases of CML-Blast Phase
Myeloid blast crisis Lymphoid blast crisis Mixed phenotypic
(n=27) (B-lineage) (n=14) blasts (n=2)
Parameters p-value
Positive Positive Positive
n % n % n %
CD13 24 92.31 4 28.57 2 100.0 <0.001
*
CD33 26 100.0 6 42.86 2 100.0 <0.001
*
*
cMPO 27 100.0 0 0.00 2 100.0 <0.001
CD64 2 22.22 0 0.00 0 0.0 0.523
*
cCD79a 0 0.00 0 - 1 100.0 0.025
CD117 16 76.19 1 10.00 1 100.0 0.002
*
CD19 2 8.70 11 91.67 1 100.0 <0.001
*
CD20 0 0.00 11 84.62 0 0.0 <0.001
*
CD10 2 8.00 13 100.00 1 100.0 <0.001
*
cCD22 0 0.00 2 100.00 1 100.0 0.821
*
CD5 0 0.00 0 0.00 1 100.0 0.002
CD7 3 12.50 0 0.00 1 50.0 0.080
cCD3 0 0.00 0 0.00 1 50.0 <0.001
*
*
CD34 26 100.00 10 76.92 2 100.0 0.031
CD38 5 50.00 5 71.43 0 - 0.598
CD25 1 11.11 1 16.67 1 50.0 0.462
*
TdT 2 10.00 9 81.82 2 100.0 <0.001
HLA-DR 24 100.00 11 100.00 1 100.0 -
*
Note. Significant (p<0.05)
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