Page 34 - IJSA, Vol. 6, No 1, 2023

International Journal of Science Annals, Vol. 6, No. 1, 2023
рrint ISSN: 2617-2682; online ISSN: 2707-3637; DOI:10.26697/ijsa

SOCIAL AND BEHAVIORAL SCIENCES. Health Care Sciences

ORIGINAL RESEARCH
Role of Lipid Profile, Apolipoproteins, and
Their Ratio for Prediction of Cardiovascular

Disease in Essential Hypertension

Authors’ Contribution: 1 ABEFG 1 ABCDE 1 ABCDEF
A – Study design; Dubey R. , Baghel D. S. , Gaikwad K. ,
B – Data collection; Rathore V. 1 ABCDEF , Saxena R. 1 BEF , Ansari Y. M. 1 BEF

C – Statistical analysis; 1
D – Data interpretation; Shyam Shah Medical College, Rewa, India
E – Manuscript preparation;
F – Literature search; Received: 06.05.2023; Accepted: 07.06.2023; Published: 30.06.2023
G – Funds collection
Abstract
Background and Dyslipidemia is a risk factor for cardiovascular disease, and lipid metabolism
Aim of Study: changes are linked to essential hypertension. The aim of the study: to investigate the
significance of lipid parameters, apolipoproteins, and their ratio in predicting
cardiovascular disease among individuals with essential hypertension.
Material and Methods: 250 patients with essential hypertension and 250 healthy control subjects were
enrolled in this case-control study and their serum lipids and apolipoproteins were
analyzed. Differences between cases and controls were examined using independent
sample t-test and, a p-value <0.05 was considered significant.
Results: In the essential hypertensive group, fasting blood glucose (FBG), total cholesterol
(TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), very low-
density lipoprotein cholesterol (VLDL-C), apolipoprotein B100 (Apo B100) and Apo
B100/Apo A1 ratio were increased significantly compared to control subjects.
Essential hypertensive patients had significantly decreased levels of apolipoprotein
A1 (Apo A1) and high-density lipoprotein cholesterol (HDL-C) compared to
controls. Moreover, age, body mass index (BMI), FBG, TC, TG, LDL-C, and VLDL-
C, as well as the Apo B100/Apo A1 ratio, were significantly positively correlated
with both systolic blood pressure (SBP) and diastolic blood pressure (DBP), but
HDL-C and Apo A1 were significantly negatively correlated in essential
hypertensive subjects. There was a significant positive correlation between apo
B100 and SBP in people with essential hypertension. Apo B100 and DBP showed a
positive association, however, it was not statistically significant.

Conclusions: Essential hypertensive people with dyslipidemia and an elevated Apo B100/Apo A1
ratio are at an increased risk for the development of cardiovascular disease.
Keywords: essential hypertension, dyslipidemia, apolipoproteins, cardiovascular disease,
systolic blood pressure, diastolic blood pressure
Copyright: © 2023 Dubey R., Baghel D. S., Gaikwad K., Rathore V., Saxena R., Ansari Y. M.
Published by Archives of International Journal of Science Annals
DOI and UDC DOI https://doi.org/10.26697/ijsa.2023.1.3 UDC 616.411:616-079
Conflict of interests: The authors declare that there is no conflict of interests
Peer review: Double-blind review
Source of support: This research did not receive any outside funding or support
Information about Dubey Rahul – https://orcid.org/0009-0001-2123-9470; Postgraduate Student,
the authors: Department of Biochemistry, Shyam Shah Medical College, Rewa, India.
Baghel Drutpal Singh – https://orcid.org/0009-0007-8078-7454; Doctor of
Philosophy in Medical Biochemistry, Professor, Shyam Shah Medical College, India.
Gaikwad Kapila – https://orcid.org/0000-0002-4265-936X; MD, Associate
Professor, Department of Biochemistry, Shyam Shah Medical College, Rewa, India.
Rathore Vedika (Corresponding Author) – https://orcid.org/0000-0001-9803-7052;
[email protected]; Doctor of Philosophy in Medical Biochemistry,
Associate Professor (Designated), Shyam Shah Medical College, Rewa, India.
Saxena Ravindra – https://orcid.org/0000-0003-2655-8531; Postgraduate Student,
Department of Biochemistry, Shyam Shah Medical College, Rewa, India.
Ansari Yar Mohammad – https://orcid.org/0009-0004-6371-9984; Postgraduate
Student, Department of Biochemistry, Shyam Shah Medical College, Rewa, India.

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